236 The Big Bang Theory The Hofstadter Isotope 02 20 2009-04-13 Comedy / Romance Jim Parsons - Sheldon Cooper / Johnny Galecki - Leonard Hofstadter / Kaley Cuoco - Penny / Kunal Nayyar - Rajesh Koothrappali / Simon Helberg - Howard Wolowitz / Melissa Rauch - Bernadette Rostenkowski / Mayim Bialik - Amy Farrah Fowler / Laura Spencer - Emily Sweeney / Sara Gilbert - Leslie Winkle / Kevin Sussman - Stuart Bloom / John Ross Bowie - Barry Kripke / Carol Ann Susi - Debbie Wolowitz When a fellow comic book enthusiast hits on Penny it leads to Leonard and Howard going to a bar's on Ladies' Night.